Dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI), has revolutionized the treatment landscape for premature ejaculation (PE). Initially developed as an antidepressant, it has found its niche in a more specialized domain. Dapoxetine’s molecular formula is C21H23NO, which constitutes a piperidine derivative. The intricate chemical structure includes a naphthalene moiety linked to a piperidine, granting it unique pharmacokinetic properties. This structure endows dapoxetine with the ability to interact with serotonin transporters effectively.

Mechanism of Action

Dapoxetine’s primary mode of action involves the modulation of serotonin levels in the synaptic cleft. It inhibits the serotonin transporter, which results in increased serotonin action in the synapse. This modulation enhances the post-synaptic receptor binding, leading to a delay in ejaculatory latency. The rapid onset and short half-life make dapoxetine an ideal choice for on-demand therapy. This is in contrast to other SSRIs used in depression, where a prolonged effect is necessary. The timing of administration and its fleeting presence in the bloodstream reduce the risk of adverse effects.

Indications

The principal indication for dapoxetine 60mg is the treatment of premature ejaculation in adult men. It is effective in patients with intravaginal ejaculatory latency time (IELT) of less than two minutes. Dapoxetine improves control over ejaculation, enhances sexual satisfaction, and reduces personal distress or interpersonal difficulty. Although it is primarily for PE, its off-label use is limited due to its distinct pharmacokinetics. The unique aspect of dapoxetine is its selective indication, differentiating it from other antidepressants. It is not recommended for the treatment of erectile dysfunction or as a general sexual enhancement product.

Cautions with Other Medicines

Co-administration with certain medicines can lead to serious interactions. Dapoxetine should not be used alongside monoamine oxidase inhibitors (MAOIs), thioridazine, or other SSRIs. A washout period is necessary when switching from these medications to dapoxetine to prevent serotonin syndrome. Caution is advised when used with potent CYP3A4 inhibitors, such as ketoconazole, due to increased plasma concentrations of dapoxetine. The potential for hypotensive episodes necessitates careful monitoring when combined with PDE5 inhibitors like sildenafil 100mg. A thorough medication history and risk assessment should precede dapoxetine initiation.

Effects of Dapoxetine

Dapoxetine 60mg significantly improves the control over ejaculation and prolongs the time to ejaculation. Patients report increased satisfaction with sexual intercourse and reduced personal distress. Common side effects include nausea, dizziness, headache, and diarrhea. These are generally transient and dose-dependent. The benefit-risk profile is favorable, with serious adverse events being rare. Patients should be informed about the possibility of orthostatic hypotension and advised to change positions slowly. Overall, dapoxetine enhances sexual confidence and quality of life in those affected by PE.

Dapoxetine for Sale Online

The online availability of dapoxetine facilitates access to treatment for PE, but caution is advised. Patients must ensure they obtain dapoxetine from reputable sources to avoid counterfeit products. Online pharmacies should be verified for authenticity and compliance with regulatory standards. Purchasing medications online can pose risks, including receiving substandard products or those without proper medical oversight. Consulting with a healthcare professional before purchasing dapoxetine online ensures safe and effective use. A prescription should be obtained prior to acquiring dapoxetine, even from legitimate online sources.

• Do not mix with MAOIs
• Monitor when combined with PDE5 inhibitors
• Consult healthcare professionals